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Measurement Across Scales

Our multidisciplinary community uses quantitative, experimental and theoretical approaches from the physical sciences to create an integrated understanding of biological systems across length scales. This approach offers new insights into fundamental biological systems and gives fresh perspectives to life sciences challenges.

Measurement Across Scales Academics
Condensed Matter Physics

Research Highlights

    • New method to mechanically detect biological materials, including extracellular vesicles (EV) in saliva samples. These EV are important in the detection of cancer, making a new method to detect them quickly, and none invasively interesting for the treatment of cancer. This research from Professor Kislon Voïtchovsy, Dr Clodomiro Cafolla et al included collaborators from RMIT University (Melbourne) as well as Durham’s Department of Physics. Find out more here.
    • An international team, including the BSI’s Professor Suzanne Fielding have developed a new rheological continuum model for biological tissue. The model couples cell shape to flow and captures both the tissue solid-liquid transition and its linear and nonlinear rheology and provides a useful framework for modelling the rheology of biological tissue. Find out more here.
    • The physical principles that govern how and when hydraulic pressure causes fracturing of membranes has never been fully explored before. These fractures have a major role in many cell development and differentiation processes, and are involved during the development of embryos. A collaboration between Dr Margarita Staykova (Durham Physics), Professor Marino Arroyo (Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology) and colleagues from the University of Cambridge and Imperial College London has studied this exciting phenomenon. The team identified rules governing the fracturing, which work in alongside with a cell’s biochemical regulation to allow careful control of these processes. Find out more about this research here.
  • Bullseye Analysis

    Professors John Girkin (Durham Physics), Carrie Ambler (Durham Biosciences) and Andrew Whiting (Durham Chemistry) have developed a new FRAP microscopy technique to detect reactive oxygen species in situ in the cell, using novel technology from the spin out company LightOx.
    Lightox image
  • New approach to assaying DNA flexibility

    This new technique developed by Dr Aakash Basu (Durham Biosciences) gives insight into the sequence-dependence of DNA flexibility via preferential enrichment of cyclizable DNA molecules from a large pool of short DNA sequences.
    Strands of DNA

Bullseye Analysis

Professors John Girkin (Durham Physics), Carrie Ambler (Durham Biosciences) and Andrew Whiting (Durham Chemistry) have developed a new FRAP microscopy technique to detect reactive oxygen species in situ in the cell, using novel technology from the spin out company LightOx.
Lightox image

New approach to assaying DNA flexibility

This new technique developed by Dr Aakash Basu (Durham Biosciences) gives insight into the sequence-dependence of DNA flexibility via preferential enrichment of cyclizable DNA molecules from a large pool of short DNA sequences.
Strands of DNA

Activities

Art-Science Collaborations - Interfacing  

This new video by artist Daksha Patel explores BSI research into membranes and interfaces. The video combines original artwork generated by creative coding methods, experimental data and the voices of scientists describing what is happening in this exciting research area. 

Daksha Patel is a multi-disciplinary artist who works across a wide range of media, materials and technologies. Her works explore multiple areas of scientific research including biophysics, biomedical science and applied mathematics. In 2020 she was awarded the ‘Brian Cox Prize for Excellence in Public Engagement with Research’. 

Interfacing was created following conversations with Margarita Staykova and members of her research group where they shared their insights and what drives them to explore this fascinating area of research. Daksha was particularly interested in hearing from scientists about unexpected outcomes in experiments, chance and creativity in their work. The final video is a dynamic interplay between striking visual imagery and the voices of BSI scientists Margarita Staykova, Kislon Voitchovsky, and Alex Brown.  

We are thrilled to announce that Interfacing has been selected for the 17th edition of the Science New Wave Festival, presented by Imagine Science Films, which takes place in New York from October 18-25, 2024. 

 

SOFI CDT

The EPSRC Centre for Doctoral Training in Soft Matter and Functional Interfaces (SOFI CDT) was launched in 2014 and led by Professor Tom McLeish FRS. Now in its second iteration SOFI2, it is led by Professor Colin Bain (Durham Chemistry) and brings together expertise from the universities of Durham, Edinburgh and Leeds and from a wide range of industrial partners.

 

Physics of Emergent Behaviour (PoEB) IV conference

The 4th edition of the IOP PoEB conference was held in Harrogate (UK) after the 2023 Physics of Life conference. The organising committee included the BSI’s Dr Margarita Staykova (Durham Physics) and the theme of the meeting was the diverse types of phase transitions found in biology.

 

  • SOFI CDT

    SOFI2 CDT brings together expertise from the Universities of Durham, Edinburgh and Leeds as well as from the industry leaders in soft matter and functional materials applictions.
  • Interfacing

    Stimulated by art-science conversations between artist Daksha Patel and Margarita Staykova (Department of Physics) the short film Interfacing has been selected for the 17th edition of the Science New Wave Festival.
    Representation of a synthetic biological membrane by artist Daksha Patel

SOFI CDT

SOFI2 CDT brings together expertise from the Universities of Durham, Edinburgh and Leeds as well as from the industry leaders in soft matter and functional materials applictions.

Interfacing

Stimulated by art-science conversations between artist Daksha Patel and Margarita Staykova (Department of Physics) the short film Interfacing has been selected for the 17th edition of the Science New Wave Festival.
Representation of a synthetic biological membrane by artist Daksha Patel

Highlight Publications

Aufderhorst-Roberts, A., & Staykova, M., 2022. Scratching beyond the surface - minimal actin assemblies as tools to elucidate mechanical reinforcement and shape change. Emerging Topics in Life Sciences, 6, 6.

Cafolla C., Philpott-Robson J., Elbourne A., Voïtchovsky K., 2024. Quantitative Detection of Biological Nanovesicles in Drops of Saliva Using Microcantilevers. ACS Applied Materials and Interfaces, 16(1), 1. 

Cirakli E., Basu A., 2023. A method for assaying DNA flexibility. Methods, 219.

Dinet C., Torres-Sánchez A., Lanfranco R., Di Michele L., Arroyo M., Staykova M., 2023. Patterning and dynamics of membrane adhesion under hydraulic stress. Nature Communications, 14(1), 1.

Fielding S.M., Cochran J.O., Huang J., Bi D., Marchetti M.C., 2023. Constitutive model for the rheology of biological tissue, Physical Review E, 108(4), 4.

Goodband, R.J., Bain, C.D., & Staykova, M., 2022. Comparative Study of Lipid- and Polymer-Supported Membranes Obtained by Vesicle Fusion. Langmuir.

Goodband, S.J., Kusumaatmaja, H., & Voïtchovsky, K., 2022. Development of a setup to characterize capillary liquid bridges between liquid infused surfaces. AIP Advances, 12, 1.

Le Nagard, L., Brown, A.T., Dawson, A., Martinez, V.A., Poon, W.C.K., & Staykova, M., 2022. Encapsulated bacteria deform lipid vesicles into flagellated swimmers. Proceedings of the National Academy of Sciences of the United States of America, 119, 34.

Panter, J. R., Konicek, A. R., King, M. A., Jusufi, A., Yeganeh, M. S., & Kusumaatmaja, H. 2023. Rough capillary rise. Communications Physics, 6, 1.

Prior, C., Panter, J., & Kusumaatmaja, H. 2022. A minimal model of elastic instabilities in biological filament bundles. Journal of the Royal Society Interface, 19, 194.

Zhang L., Bounds A., Girkin J., 2023. Monte Carlo simulations and phantom modeling for spatial frequency domain imaging of surgical wound monitoring. Journal of Biomedical Optics, 28(12), 12.

A purple dividing line

Measurement Across Scales Academics

Dr Ander Andershorst-Roberts, Department of Physics

Areas of Expertise: Soft Matter Physics

Research Interests

  • Rheology
  • Microrheology
  • Assembly and Mechanics of Cytoskeletal Networks
  • Biopolymers
  • Hydrogels

 

Professor Colin Bain, Department of Chemistry

Areas of Expertise: Complex Fluids and Interfaces 

Research Interests

  • Colloid and interface science
  • Inkjet printing of functional films
  • Fundamentals and applications of droplet drying

 

Dr Matteo T. Degiacomi, Department of Physics               

Areas of Expertise: Molecular Dynamics, Machine Learning, Computational Biophysics    

Research Interests: The development of protein-protein docking methods, and techniques combining machine learning and molecular dynamics simulations to sample protein conformational spaces. 

 

Professor Suzanne Fielding, Department of Physics         

Areas of Expertise: Soft Condensed Matter Physics 

Research Interests

  • Flow instabilities and flow-induced phase transitions 
  • Fluid-fluid demixing 
  • Viscoelastic turbulence 
  • Soft glassy rheology 
  • Biologically active suspensions

 

Professor John Girkin, Department of Physics    

Areas of Expertise: Advanced Photonics and Optical Technologies 

Research Interests

  • Advanced optical microscopy
  • Development of microfluidic technologies to study biological systems
  • Developing novel non-invasive tools for diagnosis

 

Professor Ritu Kataky, Department of Chemistry              

Areas of Expertise: Electrochemistry, Sensors  

Research Interests

  • Developing sensors and biosensors for environmental, clinical and pharmaceutical monitoring
  • Detection and Destruction of Biofilms on soft and hard surfaces

 

Professor Halim Kusumaatmaja, Department of Physics                

Areas of Expertise: Soft Matter, Biophysics 

Research Interests

  • Wetting on structured surfaces 
  • Membrane biophysics
  • Liquid-liquid phase separation 
  • Multi-stable elastic structures 
  • Colloidal self-assembly 
  • Droplet microfluidics 

 

Dr Margarita Staykova, Department of Physics  

Areas of Expertise: Biophysics, Biological Membranes, Functional Interfaces, Living Materials 

Research Interests

  • The mechano-sensitive architecture and composition of the cell interface
  • Cell-cell adhesion, encapsulation
  • Bio-hybrid systems
  • Bacterial growth 

 

Professor Kislon Voitchovsky, Department of Physics     

Areas of Expertise: Biological Physics, Experimental Soft Matter 

Research Interests

  • Solid-liquid and soft interfaces at the nanoscale
  • Interfacial phenomena 
  • Ionic effects 
  • Emergence of mesoscale order