Staff profile
Overview
https://apps.dur.ac.uk/biography/image/4099
| Affiliation | Telephone |
|---|---|
| Research Postgraduate (PhD) in the Department of Biosciences |
Biography
Structural and biochemical characterisation of DNA Topoisomerases
Graduate in Bs.c. (Hons) Microbiology and Pharmacology at University of Strathclyde in 2023 with a dissertation on Marine Actinomycetes as source of novel antibiotic compounds.At Durhan University research involves exploiting the structure of GyrA n-terminus with CcdB to investigate the interactions of the CcdA/B toxin-antitoxin system with gyrase and potentially discover novel antimicrobial approaches,such as using selective mutagenesis to remarkable amino-acid residues and individuate drug binding pockes within the gyrase-CcdB structure that can be utilised as antimicrobial targets.
Research interests
- Topoisomerases, Gyrase, Human topo II
Publications
Journal Article
- Narrow-spectrum drug repurposing: targeting Gardnerella vaginalis biofilms associated with bacterial vaginosis.Johnston, W., Smith, J., Giammarini, E., Campbell, A., Slate, A. J., Canga, E., Swanzy-Krah, M., Murali, P., Mason, M., Metcalfe, R., Short, C., & Kean, R. (2026). Narrow-spectrum drug repurposing: targeting Gardnerella vaginalis biofilms associated with bacterial vaginosis. Journal of Applied Microbiology, 137(2), Article lxag034. https://doi.org/10.1093/jambio/lxag034