Staff profile

My research group focuses on the identification, characterisation and validation of novel drug targets for the treatment of the major acute and chronic CNS pathologies. We also are developing novel all-in-one behavioural tests for both animals and humans. 

Dr Chazot has developed two new clinical development programmes over the last 20 years, one for chronic pain (Votucalis), and one for Alzheimer’s Disease (PBM-T 1068nm), the former at the pipeline stage for the company Akari Therapeutics UK, and the latter reaching the FDA Phase 2b clinical stage in the US. He is also the key academic collaborator for the Durham University spin-out company Nevrargenics, (http://nevrargenics.com), who has developed exciting new rational drug leads (RAR-M) for disease-modification in a range of neurodegenerative diseases.

Major Research Roles:

• Fellow of the Durham Institute of Research, Development, and Invention
• Northern Health Science Alliance (NHSA) Repurposing Medicines Network Representative
• Editorial Board of Ethnopharmacology (specialty section of Frontiers in Pharmacology)
• Biosciences Lead, spin-out company Nevrargenics (www.nevrargenics.com) 
• TSC Committee member, REGAIN and iREHAB Long-Covid trials
• PRESIDENT, European Histamine Research Society (EHRS) (2012-2018)
• FELLOW and AMBASSADOR, British Pharmacological Society (2012-present day)
• VICE CHAIR and CO-APPLICANT, EU COST ACTION BM0806 (2009-2013)
• CHAIR, International Union of Pharmacological Societies Subcommittee (2011-present day)
• DURHAM LGR/COMMITTEE OFFICER (2008- ) British Neuroscience Association
• PRESIDENT, Parkinson’s UK North Durham Branch (2010 – present day)
• SCIENCE EDITOR & CO-FOUNDER, Trends in Anaesthesia and Critical Care (TACC) (2010-)
• THEME EDITOR, Histamine Pharmacology 2009 and 2013 British Journal of Pharmacology
• ASSISTANT EDITOR Inflammation Research (2004-present day)
• EDITOR: European Journal of Medicinal Plants (2011- )
• FOUNDER and DIRECTOR, WOLFSON RESEARCH INSTITUTE SPECIAL INTEREST GROUP – PAIN (2012-present day)

Research Links:

Pain Academy - Durham University

Brain, Body and Behaviour Academy - Durham University

Ten Footsteps | My Live Well With Pain

Explore the Festival | My Live Well With Pain

Major Publications since 2001

1. Panula P, Chazot PL et al. (2015) International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacol Rev. 2015 Jul;67(3):601-65
2. S Abuhamdah et al. Pharmacological and neuroprotective profile of an essential oil derived from leaves of Aloysia citrodora Palau. J Pharm Pharmacol. 2015 Apr 16. doi: 10.1111/jphp.12424. [Epub ahead of print]
3. R Abuhamdah et al. Effects of chronic fluoxetine treatment on anxious behaviour of BALB/c mice in a 3-dimensional maze. Stress. 2015 (in press)
4. Chen Y, Stegaev V, Kouri VP, Sillat T, Chazot PL, Stark H, Wen JG, Konttinen YT. (2015) Identification of histamine receptor subtypes in skeletal myogenesis. Mol Med Rep. 11(4):2624-30
5. Chen Y et al Activation of histamine H₃ receptor decreased cytoplasmic Ca(2+) imaging during electrical stimulation in the skeletal myotubes. Eur J Pharmacol. 2015 May 5;754:173-8.
6. A Pini*, PL Chazot*, E Veglia, A Moggio, AC Rosa. H₃ receptor renal expression in normal and diabetic rats. (2015) Inflammation Res. (submitted) * Joint first author May;64(5):271-3
7. E Veglia, C Grange, A Pini, A Moggio, C Lanzi, G Camuss, PL Chazot⁵ and AC Rosa^. Histamine receptor functionalexpression in the human renal tubules: a comparative pharmacological evaluation. (2015) Inflammation Res. Apr;64(3-4):261-70
8. Duggett N and Chazot PL. Low-Intensity Light Therapy (1068 nm) Protects CAD Neuroblastoma Cells from β-Amyloid-Mediated Cell Death. Biology and Medicine (2015) 7 (1) in press
9. S Abuhamdah, R Abuhamdah, M-J R. Howes, S Al-Olimat, A Ennaceur PL Chazot African J Pharm Pharmacol (2015) 8, 1235-12 Neuropharmacological evaluation of a selection of Jordanian herbal plants
10. M Mahita, S Abuhamdah, A Ennaceur and PL Chazot Eur J Med Plants (2014) 4(7) Identification of a novel GABA_A receptor ligand from Aloysia citrodora Palau
11. Dib K, Perecko T, Jenei V, McFarlane C, Comer D, Brown V, Katebe M, Scheithauer T, Thurmond RL, Chazot PL, Ennis M. The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils. J Leukoc Biol. 2014 May 5. [Epub ahead of print]
12. Ballerini C, Aldinucci A, Luccarini I, Galante A, Manuelli C, Blandina P, Katebe M, Chazot PL, Masini E, Passani MB. Br J Pharmacol. 2013 170(1):67-77. Antagonism of histamine H₄ receptor exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis.
13. Stegaev V, Nies AT, Porola P, Mieliauskaite D, Sánchez-Jiménez F, Urdiales JL, Sillat T, Schwelberger HG, Chazot PL, Katebe M, Mackiewicz Z, Konttinen YT, Nordström DC. Rheumatology (Oxford). 2013 May 24. [Epub ahead of print] Histamine transport and metabolism are deranged in salivary glands in Sjogren's syndrome.
14. Grillo SL, Duggett NA, Ennaceur A, Chazot PL. J Photochem Photobiol B. 2013 Jun 5;123:13-22. Non-invasive infra-red therapy (1072nm) reduces β-amyloid protein levels in the brain of an Alzheimer's disease mouse model, TASTPM.
15. Rosa AC, Grange C, Pini A, Katebe MA, Benetti E, Collino M, Miglio G, Bani D, Camussi G, Chazot PL, Fantozzi R. Inflamm Res. 2013 Apr;62(4):357-65. H₄ receptor renal over expression in diabetic rats
16. Abuhamdah RM, van Rensburg R, Lethbridge NL, Ennaceur A, Chazot PL. Frontiers in Systems Neuroscience, 2012;6:54. Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze.
17. Wang M*, Chazot PL*, Ali S, Duckett SF, Obrenovitch TP. Br J Pharmacol. 2012 Jan;165(1):235-44. Effects of NMDA receptor antagonists with different subtype selectivities on retinal spreading depression. (* joint first author)
18. Vasily Stegaev, Tarvo Sillat, Pauliina Porola, Arno Hänninen, András Falus, Diana Mieliauskate, Edit Buzás, Ziga Rotar, Zygmunt Mackiewicz, Holger Stark, Paul L. Chazot, Yrjö T. Konttinen. (2012) Arthritic Rheum 64(8):2663-8. First identification of the histamine 4 receptors (H₄R) in healthy salivary glands and in focal sialadenitis 
19. Gutzmer R, Werfel T, Bäumer W, Kietzmann M, Chazot PL, Leurs R. Naunyn Schmiedebergs Arch Pharmacol. 2012 385(9):853-4. Well characterized antihistamine 4 receptor antibodies contribute to current knowledge of the expression and biology of the human and murine histamine 4 receptor. 
20. Burns A, Perry E, Holmes C, Francis P, Morris J, Howes MJ, Chazot PL, Lees G, Ballard C. (2011) Dement Geriatr Cogn Disord. 2011;31(2):158-64. A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease.
21. Ennaceur A, Michalikova S, van Rensburg R, Chazot PL. Neuropharmacology. 2011 Oct-Nov;61(5-6):981-91. MK-801 increases the baseline level of anxiety in mice introduced to a spatial memory task without prior habituation.
22. Shan, L, Bossers, K, Luchetti, S, Balesar, R, Lethbridge, N, Chazot, PL, Bao, A-M and Swaab, D (2011) Neurobiology of Ageing Jul;33(7):1488.e1-13. Alterations of the histaminergic system in the substantia nigra and striatum of Parkinson’s Disease patients: a post-mortem study 
23. Ennaceur A, Michalikova S, van Rensburg R, Chazot PL. Behav Brain Res. 2010 209(1):154-64. Tolerance, sensitization and dependence to diazepam in Balb/c mice exposed to a novel open space anxiety test.
24. Lethbridge NL, Chazot PL. Inflamm Res. 2010 59 Suppl 2:S197-8. Immunological identification of the mouse H₄ histamine receptor on spinal cord motor neurons using a novel anti-mouse H₄R antibody.
25. A Ennaceur, S Michalikova, R van Rensburg and PL Chazot (2010) Behavioural Brain Res 207(2):402-17.Anxiety responses in Balb/c, c57 and CD-1 mice exposed to a novel open space test.
26. A Ennaceur, S Michalikova, R van Rensburg and PL Chazot (2010) Behavioural Brain Res 207(1):84-98. Distinguishing anxiolysis and hyperactivity in an open space behavioral test.
27. V Feigin, M Hennerici, B Dubois, P Rothwell, S Evers, P-M Preux, F Bermejo Pareja, PM Lavados, K Nagata, G Logroscino, J Kesselring, D Bennett, S Barker-Collo, B Stegmayr, PL Chazot, S Li, M Brainin, W Wang (2009) Neuroepidemiology 33, 296-304 Bridging the Gap between Experimental and Non-Experimental Neuroepidemiology, and Ultimately – between Neuroepidemiological Research and Practice: Round Table Discussion at the First International Congress on Clinical Neurology and Epidemiology
28. P Giannoni, M-P Passani, D Nosi, PL Chazot, FC Shenton, AD Medhurst, L Munari, P Blandina (2009) Eur. J. Neurosci. 29, 2363-2374. Heterogeneity of histaminergic neurons in the tuberomammilary nucleus of the rat
29. Ennaceur A, Michalikova S, Chazot PL. (2009) Behavioural Brain Res. 197(2):417-34 Do rats really express neophobia towards novel objects? Experimental evidence from exposure to novelty and to an object recognition task in an open space and an enclosed space.
30. NL Lethbridge, FC Shenton and PL Chazot (2009) Inflamm. Res 58, 43-44. Generation and characterisation of the first anti-human H₃R445/453 isoform specific antibody probe.
31. R van Rensburg, DR Errington, A Ennaceur, G Lees, TP Obrenovitch and PL Chazot (2008) J Neuroscience Methods 177(2):311-6.A new model for the study of high K⁺-induced preconditioning in cultured neurons: role of N-methyl-D-aspartate and a7-nicotinic acetylcholine receptors
32. van Rijn RM, van Marle A, Chazot PL, Langemeijer E, Qin Y, Shenton FC, Lim HD, Zuiderveld OP, Sansuk K, Dy M, Smit MJ, Tensen CP, Bakker RA, Leurs R. (2008) Biochem J. 414(1):121-31. Cloning and characterization of dominant negative splice variants of the human histamine H₄ receptor.
33. S Abuhamdah, L Huang, MSJ Elliot, C Ballard, C Holmes, A Burns, EK Perry, P Francis, G Lees and PL Chazot (2008) Journal of Pharmacy and Pharmacology 60(11):1515-22. Pharmacological Profile of an essential oil derived from Lavandula with anti-agitation properties: focus on Ligand-gated ion channels (LGICs) 
34. W Bäumer, S Wendorff, R Gutzmer, T Werfel, D Dijkstra, PL Chazot, H Stark and M. Kietzmann (2008) Allergy 63(10):1387-94. Dendritic cell migration through skin is modulated via the histamine H₄ receptor. Implications for an immunomodulatory role of histamine
35. A Ennaceur, S Michalikova, R van Rensburg and PL Chazot (2008b) Behavioural Brain Res. 188(1):136-153 Are benzodiazepines really anxiolytics? Evidence from multiple strains of mice with variable levels of innate anxiety in the 3D maze
36. S Abuhamdah, L Huang, MSJ Elliot, C Ballard, C Holmes, A Burns, EK Perry, P Francis, G Lees and PL Chazot (2008) Journal of Pharmacy and Pharmacology 60(3):377-84. Pharmacological Profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on Ligand-gated ion channels (LGICs)
37. D Grandi, FC Shenton, PL Chazot and G Morini (2008) Inflammation Res (Suppl.) 57 Suppl 1:S57-8. Differential expression of histamine H₃ and H₄ receptors on endocrine cells in the rat gastrointestinal tract
38. MSJ Elliot, S Abuhamdah, M.J.R. Howes, C Ballard, C Holmes, A Burns, G Lees, PL Chazot, P Francis and EK Perry (2008) International Journal of Essential Oil Therapeutics Pharmacological Profile of two essential oils derived from Melissa officinalis and Lavendula angustifolia with anti-agitation properties
39. D Dijkstra, H Stark, PL Chazot, FC Shenton, R Leurs, T Werfel and R Gutzmer (2008) J Clin Invest Dermatology 128(7):1696-703. Human inflammatory dendritic epidermal cells (IDEC) express a functional histamine H₄ receptor
40. D Grandi, FC Shenton, PL Chazot and G Morini (2008) Histology and Histopathology 23(7):789-98. Immunolocalisation of histamine H₃ receptors on endocrine cells in the rat gastrointestinal tract
41. A Ennaceur, S Michalikova, R van Rensburg and PL Chazot (2008a) Behavioural Brain Res. 187(2):312-26. Detailed Analysis of the Behavior and Memory Performance of Middle-aged male and female CD-1 mice in a 3D maze
42. Michalikova S, Ennaceur A, van Rensburg R, Chazot PL. Neurobiol Learn Mem. 2008 May;89(4):480-8. Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: effects of low infrared light.
43. PL Chazot, FC Shenton, W. Schunack, D. Grandi and G. Morini (2007) Inflammation Res. Suppl 1:S19-20. Influence of (R)-α-Methylhistamine on the histamine H₃ receptor in the rat gastrointestinal tract
44. D Dijkstra , R Leurs, PL Chazot, FC Shenton, H Stark, T Werfel and R Gutzmer (2007) Journal of Allergy and Clinical Immunology 120(2):300-307.  Histamine down-regulates monocyte CCL2 production via the histamine H₄ receptor
45. KE Cannon, PL Chazot, V Hann, FC Shenton, LB Hough and F Rice (2006) Pain 129(1-2):76-92. Spinal Histamine H₃ receptor-mediated antinociception and localization on Sensory neurons
46. PL Chazot*, R Van Rijn*, FC Shenton, RA Bakker and R Leurs (2006) Mol. Pharmacol. 70, 604-615 Homo and hetero-oligomerisation of the human histamine H4 receptor (*joint first author)
47. A Ennaceur, S Michalikova, ST Wilson and PL Chazot (2006) Behavioural Brain Res. 171 26-49. Models of anxiety: rat responses to novelty in an open space and enclosed space 3 MOST DOWNLOADED ARTICLE FOR THIS JOURNAL 2006
48. A Ennaceur, S Michalikova, R van Rensburg and PL Chazot (2006) Behavioural Brain Res 174, 9-38. Models of anxiety: responses of mice to novelty and open spaces in a 3D-maze
49. RA Bakker, AF Lozada, A Van Marle, FC Shenton, RM Van Rijn, K Karlstedt, M Hoffmann, M Lintunen, Y Yamamoto, G Drutel, PL Chazot, P Panula and R Leurs (2006) Mol Pharmacol. 69, 1194-1206. Discovery of naturally occurring splice variants of the rat histamine H₃ receptor that act as dominant negatives
50. FC Shenton and PL Chazot (2005) Inflammation Res. 55, 55, 40-41. Probing the importance of N-glycosylation for [³H] clobenpropit binding to human H₃ receptors expressed in HEK 293 cells
51. Abuhamdah, S, Fuerstner, A, Lees, G and Chazot, PL (2005) Biochem. Pharmacol. 70, 1382-1388. Pharmacological binding studies of caloporoside and novel congeners with contrasting effects upon [³⁵S] TBPS binding to mammalian GABA_A receptor
52. Bradford, A, Barlow, A and Chazot PL (2005) Photochemistry and Photobiology B: Biology 81, 9-14. Probing the effects of infrared light sources IR1072 and IR880 on human lymphocytes: evidence of cytoprotection by IR1072 through an NO-mediated pathway
53. FC Shenton, V Hann and PL Chazot (2005) Inflammation Res. 54, 48-49 Evidence for native and cloned H₃ histamine receptor higher oligomers
54. V Hann, FC Shenton and PL Chazot (2004) Inflammation Res. 53, 67-68 GTP-insensitive agonist binding to native and recombinant H₃ receptors
55. N Rezai, C Duggan, D Cairns, G Lees and PL Chazot (2003) Biochem. Pharmacol. 65, 619-623 Positive modulation of [³H] TBOB binding to rat brain GABA_A receptors by simple disaccharide sugars
56. PL Chazot, OV Godukhin, A McDonald and TP Obrenovitch^. (2002) J. Neurochem. 83 1235-1238. Spreading Depression-induced preconditioning in the mouse cortex: Differential changes in the protein expression of ionotropic nicotinic acetylcholine and glutamate receptors
57. M Beck, K Brickley, HL Wilkinson, S Sharma, M Smith, PL Chazot, S Pollard and FA Stephenson (2002) J. Biol. Chem. 277, 30079-30090 Identification, molecular cloning and characterisation of a novel GABA_A receptor associated protein, GRIF-1
58. PL Chazot, S Lawrence and CL Thompson. (2002) Neuropharmacology 42, 319-324. Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2B-selective NMDA receptor antagonists
59. CL Thompson, DL Drewery, HD Atkins, FA Stephenson and PL Chazot. (2002) Molecular Brain Res. 102, 55-61. Immunohistochemical localisation of NMDA receptor subunits in the mammalian hippocampal formation: Evidence for a unique role for the NR2D subunit.
60. T Obrenovitch, O Godukhin and PL Chazot (2002) Neurosci. Letts. 320, 161-163. Repetitive Spreading Depression induces Nestin protein expression in the cortex of rats and mice. Is up-regulation initiated by NMDA receptors?
61. PL Chazot, V Hann, C Wilson, G Lees and CL Thompson. (2001) NeuroReport 12 (2) 259-262. Immunological identification of the mammalian H₃ histamine receptor in the adult mouse brain. 

Current Academic Role:

• Module Leader Ageing
• Library Tutor
• Industrial Placement Tutor
• Director, WRIHW Pain Challenge Academy
• Hatfield College Mentor

Previous Academic Roles:

• Deputy Director of the Wolfson Research Institute for Heatlth and Wellbeing
• Module Leader Pharmacology
• Module Leader Neuroscience
• Module Leader Biology of Disease
• Admissions Tutor Biomedical Sciences
• Pharmacology co-ordinator Phase 1 Medicine
• Hatfield College Committee member
• External Examiner - Biomedical Sciences, Pharmacology & Intercalated Medical Degrees (University of Bradford)

Supervision Information:

• Mr Francis Olaolorun (1:1 Commonwealth PhD student) with the University of Ibadan, Nigeria.
• Dr Amna Aurooj, PDRA (Co-supervisor)
• Dr Gurashish Singh, PDRA (Co-supervisor) in Engineering

• Prof Chazot’s group is interested in identifying, studying and validating novel drug targets for treating acute brain damage and a range of common chronic neuro- and immuno-pathologies.
• His favourite molecules to study are histamine (http://www.ehrs.org.uk/ and http://www.histamineresearch.com) and glutamate.
• Technologies employed include immunobiochemistry, molecular biology, ligand autoradiography, radioligand binding, heterologous expression, primary neuronal cultures, adenoviral transfection, in vitro electrophysiology, in vivo behavioural testing

Chapter in book

• Jiang, Z., Chazot, P., & Jiang, R. (in press). Review on Social Behaviour Analysis of Laboratory Animals: from Methodologies to Applications. In R. Jiang, L. Zhang, H.-L. Wei, D. Crookes, & P. Chazot (Eds.), Recent Advances in AI-enabled Automated Medical Diagnosis. Routledge
• Zhang, Z., Jiang, R., Crookes, D., & Chazot, P. (2022). Machine Learning based Biological Ageing Estimation: A Survey. In R. Jiang, L. Zhang, H.-L. Wei, D. Crookes, & P. Chazot (Eds.), Recent Advances in AI-enabled Automated Medical Diagnosis. Routledge
• Liu, G., Zhang, Z., Jiang, R., Crookes, D., & Chazot, P. (2022). EEG-based Deep Emotional Diagnosis: A Comparative Study. In R. Jiang, L. Zhang, H.-L. Wei, D. Crookes, & P. Chazot (Eds.), Recent Advances in AI-enabled Automated Medical Diagnosis. Routledge. https://doi.org/10.1201/9781003176121
• Berman, M. H., Hamblin, M. R., & Chazot, P. (2017). Photobiomodulation and Other Light Stimulation Procedures. In J. R. Evans, & R. Turner (Eds.), Rhythmic stimulation procedures in neuromodulation (97-129). Academic Press. https://doi.org/10.1016/b978-0-12-803726-3.00004-3
• Shenton, F. C., Lethbridge, N., & Chazot, P. L. (2017). Development, Characterization, and Validation of Anti-Human H3 Receptor Isoform-Specific Antibodies. In E. Tiligada, & M. Ennis (Eds.), Histamine receptors as drug targets (19-47). Springer Verlag. https://doi.org/10.1007/978-1-4939-6843-5_2

Edited book

• Jiang, R., Zhang, L., Wei, H.-L., Crookes, D., & Chazot, P. (Eds.). (2022). Recent Advances in AI-enabled Automated Medical Diagnosis. Routledge

Journal Article

• Johnson, L., Cole, F., Kinchin, R., Francis, A., Winiarek, K., Hampshire, K., & Chazot, P. (online). Assessing the feasibility of the GOTT (Gabapentinoid and Opioid Tapering Toolkit) in a primary care setting in North-East England. British Journal of Pain, https://doi.org/10.1177/20494637241291534
• Ladagu, A., Olopade, F., Chazot, P., Elufioye, T., Luong, T., Fuller, M., Halprin, E., Mckay, J., Ates-Alagoz, Z., Gilbert, T., Adejare, A., & Olopade, J. (2024). ZA-II-05, a novel NMDA-receptor antagonist reverses vanadium-induced neurotoxicity in Caenorhabditis elegans ( C. elegans). BMC Neuroscience, 25(1), Article 56. https://doi.org/10.1186/s12868-024-00902-y
• JianHua, Z., Li, M., Hu, Q., Donoghue, P., Jiang, S., Li, J., Li, S., Ren, X., Zhang, Z., Du, J., Yu, Y., Chazot, P., & Lu, C. (2024). CaMKIIα‐TARPγ8 signaling mediates hippocampal synaptic impairment in aging. Aging Cell, Article e14349. https://doi.org/10.1111/acel.14349
• Escudier, O., Zhang, Y., Whiting, A., & Chazot, P. (2024). Evaluation of a Synthetic Retinoid, Ellorarxine, in the NSC-34 Cell Model of Motor Neuron Disease. International Journal of Molecular Sciences, 25(18), Article 9764. https://doi.org/10.3390/ijms25189764
• Alanazi, N., Fitzgerald, M., Hume, P., Hellewell, S., Horncastle, A., Anyaegbu, C., Papini, M. G., Hargreaves, N., Halicki, M., Entwistle, I., Hind, K., & Chazot, P. (2024). Concussion-Related Biomarker Variations in Retired Rugby Players and Implications for Neurodegenerative Disease Risk: The UK Rugby Health Study. International Journal of Molecular Sciences, 25(14), Article 7811. https://doi.org/10.3390/ijms25147811
• Penlington, C., Pornsukjantra, P., Chazot, P., Cole, F., & Denneny, D. (2024). Confidence of practitioners to support self-management of pain: A multidisciplinary survey. British Journal of Pain, 18(2), 148-154. https://doi.org/10.1177/20494637231212748
• Chindo, B. A., Howes, M.-J. R., Abuhamdah, S., Mallam, D., Micah, T., Awotula, R. I., Battison, R., & Chazot, P. L. (2024). Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models. Journal of Ethnopharmacology, 321, Article 117500. https://doi.org/10.1016/j.jep.2023.117500
• Digal Ladagu, A., Eniola Olopade, F., Chazot, P., Oyagbemi, A. A., Ohiomokhare, S., Racheal Folarin, O., Tashara Gilbert, T., Fuller, M., Luong, T., Adejare, A., & Olopade, J. O. (2023). Attenuation of Vanadium-Induced Neurotoxicity in Rat Hippocampal Slices (In Vitro) and Mice (In Vivo) by ZA-II-05, a Novel NMDA-Receptor Antagonist. International Journal of Molecular Sciences, 24(23), Article 16710. https://doi.org/10.3390/ijms242316710
• Halicki, M. J., Hind, K., & Chazot, P. L. (2023). Blood-Based Biomarkers in the Diagnosis of Chronic Traumatic Encephalopathy: Research to Date and Future Directions. International Journal of Molecular Sciences, 24(16), Article 12556. https://doi.org/10.3390/ijms241612556
• Chazot, P., Cowart, M., Fukui, H., Ganellin, C. R., Gutzmer, R., Haas, H. L., Hill, S. J., Hills, R., Leurs, R., Levi, R., Liu, S., Panula, P., Schunack, W., Schwartz, J.-C., Seifert, R., Shankley, N. P., Stark, H., Thurmond, R., Timmerman, H., & Young, J. M. (2023). Histamine receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023(1), https://doi.org/10.2218/gtopdb/f33/2023.1
• Johnson, M. I., Chazot, P., Cole, F., Cruickshank, R., Fuller, D., Keyse, C., Singh, B., Strickson, A. J., Tabasam, G., Tregidden, E., Thompson, K., & Woodall, J. (2023). Pain through the perspective of art and creativity: insights from the Unmasking Pain project. Frontiers in Pain Research, 4, Article 1179116. https://doi.org/10.3389/fpain.2023.1179116
• Mcauley, E., Johnston, L., Johnston, P., Shaw, J., Bonner, S., & Chazot, P. L. (2022). Carol's journey in critical care: An Enlighten Project case study. Trends in Anaesthesia and Critical Care, 44, 3-7. https://doi.org/10.1016/j.tacc.2022.03.001
• Jiang, R., Chazot, P., Pavese, N., Crookes, D., Bouridane, A., & Celebi, M. E. (2022). Private Facial Prediagnosis as an Edge Service for Parkinson's DBS Treatment Valuation. IEEE Journal of Biomedical and Health Informatics, 26(6), 2703-2713. https://doi.org/10.1109/jbhi.2022.3146369
• Hind, K., Konerth, N., Entwistle, I., Hume, P., Theadom, A., Lewis, G., King, D., Goodbourn, T., Bottiglieri, M., Ferraces-Riegas, P., Ellison, A., & Chazot, P. (2022). Mental health and wellbeing of retired elite and amateur rugby players and non-contact athletes and associations with sports-related concussion: the UK Rugby Health Project. Sports Medicine, 52(6), 1419-1431. https://doi.org/10.1007/s40279-021-01594-8
• Chazot, P. (2022). Molecular Biology of Histamine System, volume 1. International Journal of Molecular Sciences, 23(9), Article 5026. https://doi.org/10.3390/ijms23095026
• Kitchen, L. C., Berman, M., Halper, J., & Chazot, P. (2022). Rationale for 1068 nm Photobiomodulation Therapy (PBMT) as a Novel, Non-Invasive Treatment for COVID-19 and Other Coronaviruses: Roles of NO and Hsp70. International Journal of Molecular Sciences, 23(9), Article 5221. https://doi.org/10.3390/ijms23095221
• Spedding, M., Sebban, C., Jay, T. M., Rocher, C., Tesolin-Decros, B., Chazot, P., Schenker, E., Szénási, G., Lévay, G. I., Megyeri, K., Barkóczy, J., Hársing, L. G., Thomson, I., Cunningham, M. O., Whittington, M. A., Etherington, L.-A., Lambert, J. J., Antoni, F. A., & Gacsályi, I. (2022). Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile. Cells, 11(7), Article 1181. https://doi.org/10.3390/cells11071181
• Chazot, P. (2022). The H4 histamine receptor, a new rational neuroinflammatory target for Parkinson’s disease: A commentary. Brain, Behavior, and Immunity, 100, 231-232. https://doi.org/10.1016/j.bbi.2021.12.013
• Zhang, Z., Jiang, R., Zhang, C., Williams, B., Jiang, Z., Li, C.-T., Chazot, P., Pavese, N., Bouridane, A., & Beghdadi, A. (2022). Robust Brain Age Estimation based on sMRI via Nonlinear Age-Adaptive Ensemble Learning. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 30, 2146-2156. https://doi.org/10.1109/tnsre.2022.3190467
• Alrashdi, I., Alsubaiyel, A., Chan, M., Battell, E. E., Ennaceur, A., Nunn, M. A., Weston-Davies, W., Chazot, P. L., & Obara, I. (2022). Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice. Frontiers in Pharmacology, 13, Article 846683. https://doi.org/10.3389/fphar.2022.846683
• Némethy, Z., Kiss, B., Lethbridge, N., Chazot, P., Hajnik, T., Tóth, A., Détári, L., Schmidt, É., Czurkó, A., Kostyalik, D., Oláh, V., Hernádi, I., Balázs, O., Vizi, E. S., Ledneczki, I., Mahó, S., Román, V., Lendvai, B., & Lévay, G. (2022). Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H3 receptor antagonist/inverse agonist. European Journal of Pharmacology, 916, https://doi.org/10.1016/j.ejphar.2021.174621
• Rosa, A. C., Nardini, P., Sgambellone, S., Gurrieri, M., Spampinato, S. F., Dell’Accio, A., Chazot, P. L., Obara, I., Liu, W. L., & Pini, A. (2022). CNS-Sparing Histamine H3 Receptor Antagonist as a Candidate to Prevent the Diabetes-Associated Gastrointestinal Symptoms. Biomolecules, 12(2), https://doi.org/10.3390/biom12020184
• Quade, L., Chazot, P., & Gowland, R. (2021). Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures. American journal of physical anthropology, 174(3), 532-541. https://doi.org/10.1002/ajpa.24157
• Qi, X., Nizamutdinov, D., Berman, M. H., Dougal, G., Chazot, P. L., Wu, E., Stevens, A., Yi, S., & Huang, J. H. (2021). Gender Differences of Dementia in Response to Intensive Self-Administered Transcranial and Intraocular Near-Infrared Stimulation. Curēus, 13(7), Article e16188. https://doi.org/10.7759/cureus.16188
• Verta, R., Gurrieri, M., Borga, S., Benetti, E., Pollicino, P., Cavalli, R., Thurmond, R. L., Chazot, P. L., Pini, A., Rosa, A. C., & Grange, C. (2021). The Interplay between Histamine H4 Receptor and the Kidney Function: The Lesson from H4 Receptor Knockout Mice. Biomolecules, 11(10), https://doi.org/10.3390/biom11101517
• Chindo, B. A., Howes, M.-J. R., Abuhamdah, S., Yakubu, M. I., Ayuba, G. I., Battison, A., & Chazot, P. L. (2021). New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm). Frontiers in Pharmacology, 12, https://doi.org/10.3389/fphar.2021.760674
• Hind, K., Konerth, N., Entwistle, I., Lewis, G., Theadam, A., & Chazot, P. (2020). Cumulative sport‑related injuries and longer term impact in retired male elite‑ and amateur‑level rugby code athletes and non‑contact athletes : a retrospective study. Sports Medicine, 50(11), 2051-2061. https://doi.org/10.1007/s40279-020-01310-y
• Ohiomokhare, S., Olaolorun, F., Ladagu, A., Olopade, F., Howes, M.-J. R., Okello, E., Olopade, J., & Chazot, P. L. (2020). The Pathopharmacological Interplay between Vanadium and Iron in Parkinson’s Disease Models. International Journal of Molecular Sciences, 21(18), Article 6719. https://doi.org/10.3390/ijms21186719
• Sharifi-Rad, M., Lankatillake, C., Dias, D. A., Docea, A. O., Mahomoodally, M. F., Lobine, D., Chazot, P. L., Kurt, B., Boyunegmez Tumer, T., Catarina Moreira, A., Sharopov, F., Martorell, M., Martins, N., Cho, W. C., Calina, D., & Sharifi-Rad, J. (2020). Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics. Journal of Clinical Medicine, 9(4), Article 1061. https://doi.org/10.3390/jcm9041061
• Obara, I., Telezhkin, V., Alrashdi, I., & Chazot, P. L. (2020). Histamine, histamine receptors and neuropathic pain relief. British Journal of Pharmacology, 177(3), 580-599. https://doi.org/10.1111/bph.14696
• Chazot, P. L., Johnston, L., Mcauley, E., & Bonner, S. (2019). Histamine and Delirium: Current Opinion. Frontiers in Pharmacology, 10, Article 299. https://doi.org/10.3389/fphar.2019.00299
• Jiang, Z., Chazot, P. L., Celebi, M. E., Crookes, D., & Jiang, R. (2019). Social Behavioral Phenotyping of Drosophila with a 2D-3D Hybrid CNN Framework. IEEE Access, 7, 67972-67982. https://doi.org/10.1109/access.2019.2917000
• Todd, A., Akhter, N., Cairns, J.-M., Kasim, A., Walton, N., Ellison, A., Chazot, P., Eldabe, S., & Bambra, C. (2018). The Pain Divide: a cross-sectional analysis of chronic pain prevalence, pain intensity and opioid utilisation in England. BMJ Open, 8(7), Article e023391. https://doi.org/10.1136/bmjopen-2018-023391
• Kennedy, D., Okello, E., Chazot, P., Howes, M.-J., Ohiomokhare, S., Jackson, P., Haskell-Ramsay, C., Khan, J., Forster, J., & Wightman, E. (2018). Volatile Terpenes and Brain Function: Investigation of the Cognitive and Mood Effects of Mentha × Piperita L. Essential Oil with In Vitro Properties Relevant to Central Nervous System Function. Nutrients, 10(8), Article 1029. https://doi.org/10.3390/nu10081029
• Allen, S. J., Dixon, C. J., & Chazot, P. L. (2018). Can H2 -receptor upregulation and raised histamine explain an anaphylactoid reaction on cessation of ranitidine in a 19-year-old female? A case report. British Journal of Clinical Pharmacology, 84(7), 1611-1616. https://doi.org/10.1111/bcp.13578
• Pini, A., Grange, C., Veglia, E., Argenziano, M., Cavalli, R., Guasti, D., Calosi, L., Ghè, C., Solarino, R., Thurmond, R. L., Camussi, G., Chazot, P. L., & Rosa, A. C. (2018). Histamine H 4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice. Pharmacological Research, 128, 18-28. https://doi.org/10.1016/j.phrs.2018.01.002
• Lobine, D., Cummins, I., Govinden-Soulange, J., Ranghoo-Sanmukhiya, M., Lindsey, K., Chazot, P., Ambler, C., Grellscheid, S., Sharples, G., Lall, N., Lambrechts, I., Lavergne, C., & Howes, M.-J. (2018). Medicinal Mascarene Aloe s: An audit of their phytotherapeutic potential. Fitoterapia, 124, 120-126. https://doi.org/10.1016/j.fitote.2017.10.010
• Abuhamdah, S., Shatarat, A., Al-Essa, M., Al-Ameer, H., Al-Olimat, S., & Chazot, P. (2017). Spasmolytic and Antimicrobial Activities of Crude Extract of Bongardia chrysogonum L. Tubers. International Journal of Pharmacology, 14(1), 52-60. https://doi.org/10.3923/ijp.2018.52.60
• Abuhamdah, S. M., Abuirmeile, A. N., Thaer, F., Al-Olimat, S., Abdel, E., & Chazot, P. L. (2017). Anti-convulsant Effects of Bongardia chrysogonum L. Tuber in the Pentylenetetrazole-induced Seizure Model. International Journal of Pharmacology, 14(1), 127-135. https://doi.org/10.3923/ijp.2018.127.135
• Lobine, D., Howes, M.-J., Cummins, I., Govinden-Soulange, J., Ranghoo-Sanmukhiya, M., Lindsey, K., & Chazot, P. (2017). Bio-prospecting endemic Mascarene Aloes for potential neuroprotectants. Phytotherapy Research, 31(12), 1926-1934. https://doi.org/10.1002/ptr.5941
• Ennaceur, A., Hussain, M., Abuhamdah, R., Mostafa, R., & Chazot, P. (2017). Slope climbing challenges, fear of heights, anxiety and time of the day. Behavioural Brain Research, 316, 169-182. https://doi.org/10.1016/j.bbr.2016.09.010
• Lethbridge, N., & Chazot, P. (2016). Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies. Pharmacological Research, 113(Part A), 245-256. https://doi.org/10.1016/j.phrs.2016.08.034
• Veglia, E., Pini, A., Moggio, A., Grange, C., Premoselli, F., Miglio, G., Tiligada, K., Fantozzi, R., Chazot, P. L., & Rosa, A. C. (2016). Histamine type 1-receptor activation by low dose of histamine undermines human glomerular slit diaphragm integrity. Pharmacological Research, 114, 27-38. https://doi.org/10.1016/j.phrs.2016.10.011
• Abuhamdah, R., Hussain, M., Chazot, P., & Ennaceur, A. (2016). Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine. Physiology & Behavior, 164(Part A), 353-360. https://doi.org/10.1016/j.physbeh.2016.06.017
• Pini, A., Obara, I., Battell, E., Chazot, P., & Rosa, A. (2016). Histamine in diabetes: is it time to reconsider?. Pharmacological Research, 111, 316-324. https://doi.org/10.1016/j.phrs.2016.06.021
• Lucarini, L., Pini, A., Rosa, A., Lanzi, C., Durante, M., Chazot, P., Krief, S., Schreeb, A., Stark, H., & Masini, E. (2016). Role of Histamine H4 Receptor ligands in Bleomycin-induced pulmonary fibrosis. Pharmacological Research, 111, 740-748. https://doi.org/10.1016/j.phrs.2016.07.037
• Cork, S., Chazot, P., & Pyner, S. (2016). Altered GABAA α5 subunit expression in the hypothalamic paraventricular nucleus of hypertensive and pregnant rats. Neuroscience Letters, 620, 148-153. https://doi.org/10.1016/j.neulet.2016.03.031
• Ennaceur, A., & Chazot, P. (2016). Preclinical animal anxiety research - flaws and prejudices. Pharmacology Research and Perspectives, 4(2), https://doi.org/10.1002/prp2.223
• Wang, J., Wang, Y., Xu, F., Zhao, J., Zhou, S., Yu, Y., Chazot, P., Wang, X., & Lu, C. (2016). Activity- and development-dependent down-regulation of TARPγ8 and GluA1 in cultured rat hippocampal neurons. Acta Pharmacologica Sinica, 37(3), 303-311. https://doi.org/10.1038/aps.2015.112
• Abuhamdah, R., Hussain, M., Chazot, P., & Ennaceur, A. (2015). Effects of chronic fluoxetine treatment on anxious behaviour of BALB/c mice in a 3-dimensional maze. Stress: The International Journal on the Biology of Stress, 18(6), 677-685. https://doi.org/10.3109/10253890.2015.1083550
• Abuhamdah, S., Abuhamdah, R., Howes, M., Al-Olimat, S., Ennaceur, A., & Chazot, P. (2015). Pharmacological and neuroprotective profile of an essential oil derived from leaves of Aloysia citrodora Palau. Journal of Pharmacy and Pharmacology, 67(9), 1306-1315. https://doi.org/10.1111/jphp.12424
• Panula, P., Chazot, P., Cowart, M., Gutzmer, R., Leurs, R., Liu, W., Stark, H., Thurmond, R., & Haas, H. (2015). International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacological Reviews, 67(3), 601-655. https://doi.org/10.1124/pr.114.010249
• Chen, Y., Paavola, J., Stegajev, V., Stark, H., Chazot, P., Wen, J., & Konttinen, Y. (2015). Activation of histamine H3 receptor decreased cytoplasmic Ca(2+) imaging during electrical stimulation in the skeletal myotubes. European Journal of Pharmacology, 754, 173-178. https://doi.org/10.1016/j.ejphar.2015.02.035
• Pini, A., Chazot, P. (. 1. A., Veglia, E., Moggio, A., & Rosa, A. (2015). H3 receptor renal expression in normal and diabetic rats. Inflammation Research, 64(5), 271-273. https://doi.org/10.1007/s00011-015-0808-y
• Chen, Y., Stegaev, V., Kouri, V., Sillat, T., Chazot, P., Stark, H., Wen, J., & Konttinen, Y. (2015). Identification of histamine receptor subtypes in skeletal myogenesis. Molecular Medicine Reports, 11(4), 2624-2630. https://doi.org/10.3892/mmr.2014.3073
• Veglia, E., Grange, C., Pini, A., Moggio, A., Lanzi, C., Camussi, G., Chazot, P., & Rosa, A. (2015). Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation. Inflammation Research, 64(3-4), 261-270. https://doi.org/10.1007/s00011-015-0807-z
• Dib, K., Perecko, T., Jenei, V., McFarlane, C., Comer, C., Brown, V., Katebe, M., Scheithauer, T., Thurmond, R., Chazot, P., & Ennis, M. (2014). The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils. Journal of Leukocyte Biology, 96(3), 411-419. https://doi.org/10.1189/jlb.2ab0813-432rr
• Wang, M., Chazot, P., Ali, S., Duckett, S., & Obrenovitch, T. (2012). Effects of NMDA receptor antagonists with different subtype selectivities on retinal spreading depression. British Journal of Pharmacology, 165(1), 235-244. https://doi.org/10.1111/j.1476-5381.2011.01553.x
• Ennaceur, A., Michalikova, S., van Rensburg, R., & Chazot, P. (2011). MK-801 increases baseline level of anxiety in mice introduced to a spatial memory task without prior habituation. Neuropharmacology, 61(5-6), 981-991. https://doi.org/10.1016/j.neuropharm.2011.06.027
• Ennaceur, A., Michalikova, S., & Chazot, P. (2009). Do rats really express neophobia towards novel objects? Experimental evidence from exposure to novelty and to an object recognition task in an open space and an enclosed space. Behavioural Brain Research, 197(2), 417-434. https://doi.org/10.1016/j.bbr.2008.10.007
• Connolly, W., Shenton, F., Lethbridge, N., Leurs, R., Waldvogel, H., Faull, R., Lees, G., & Chazot, P. (2009). The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. British Journal of Pharmacology, 157(1), 55-63. https://doi.org/10.1111/j.1476-5381.2009.00227.x
• van Rensburg, R., Errington, D., Ennaceur, A., Lees, G., Obrenovitch, T., & Chazot, P. (2009). A new model for the study of high-K(+)-induced preconditioning in cultured neurones: role of N-methyl-d-aspartate and alpha7-nicotinic acetylcholine receptors. Journal of Neuroscience Methods, 177(2), 311-316. https://doi.org/10.1016/j.jneumeth.2008.10.012
• Dijkstra, D., Stark, H., Chazot, P., Shenton, F., Leurs, R., Werfel, T., & Gutzmer, R. (2008). Human Inflammatory Dendritic Epidermal Cells Express a Functional Histamine H4 Receptor. Journal of Investigative Dermatology, 128(7), 1696-1703. https://doi.org/10.1038/sj.jid.5701250
• Van Rijn, R., Chazot, P., Shenton, F., Sansuk, K., Bakker, R., & Leurs, R. (2006). Oligomerization of recombinant and endogenously expressed human histamine H4 receptors. Molecular Pharmacology, 70(2), 604-615. https://doi.org/10.1124/mol.105.020818
• Abuhamdah, S., Fuerstner, A., Lees, G., & Chazot, P. (2005). Radioligand binding studies of caloporoside and novel congeners with contrasting effects upon [35S] TBPS binding to the mammalian GABAA receptor. Biochemical Pharmacology, 70(9), 1382-1388. https://doi.org/10.1016/j.bcp.2005.07.026
• Chazot, P., Godukhin, O., McDonald, A., & Obrenovitch, T. (2002). Spreading Depression-induced preconditioning in the mouse cortex: Differential changes in the protein expression of ionotropic nicotinic acetylcholine and glutamate receptors. Journal of Neurochemistry, 83(5), 1235-1238. https://doi.org/10.1046/j.1471-4159.2002.01240.x
• Chazot, P., Lawrence, S., & Thompson, C. (2002). Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2B-selective NMDA receptor antagonists. Neuropharmacology, 42(3), 319-324. https://doi.org/10.1016/s0028-3908%2801%2900191-5