CHEM3421: ADVANCED BIOLOGICAL CHEMISTRY

• Core Chemistry 2 (CHEM2012) AND [Biological Chemistry (CHEM2051) OR Biochemistry (BIOL2491)].

• Inorganic Concepts and Applications (CHEM3097) OR Advanced Organic Chemistry (CHEM3117) OR Molecules and their Interactions (CHEM3137).

• This module may not be taken in the same year of study as Computational Chemistry (CHEM2061) or Computational Chemical Physics (CHEM3151).

• To emphasise and expand undergraduates' application of chemical knowledge and analytical methods to biological systems.
• This will be achieved by both lecture based teaching and through project work that introduces computer-based searching of recent biochemical literature, particularly spectroscopic information.

• Nucleosides, nucleotides and nucleic acids: structures, synthesis. Biological roles and applications in chemical biology.
• Kinetic and mechanistic overview of the reactivity of enzymes.
• Design and utility of molecular probes in various biological systems.
• Survey of the key structural elements in proteins and the relationships to their constitution. The function of selected proteins and protein folding.

Subject-specific Knowledge:

• Understand the roles of nucleosides, nucleotides and nucleic acids in biological systems, how these materials can be synthesised chemically and biologically, and how they can be applied to solving biological problems.
• Understand the function of enzymes in biochemical pathways, apply models which describe the kinetics of enzyme catalysed reactions, and understand how small molecules may be used to modulate enzyme activity.
• Understand the principles underlying the design of molecular probes for biological systems, and how probes can be applied to further biological understanding.
• Advanced understanding of the structure and reactivity of amino-acids, peptides and proteins.
• Investigate the structure-function relationship of proteins.

Subject-specific Skills:

• Use of a range of databases such as UNIPROT and the Protein Data Bank to analyse protein structures.
• Use of on-line bioinformatic tools to investigate structure-function relationships of proteins.

Key Skills:

• Group working, encouraged and developed through workshop teaching and the coursework.
• Written communication advanced through the use of essay type questions in lecture-support worksheets and the coursework.
• Problem-solving developed through workshops.
• Information retrieval through the coursework.
• IT skills, improved through database searching, introduced in the coursework.

• Lectures are used to convey concepts, demonstrate what is required to be learned and to illustrate the application of theory to practical examples. When appropriate, lectures will be supported by written on-line material, or by information and relevant links on Blackboard Learn Ultra.
• Workshops are where groups of students consider problems and explore common shared difficulties. Problem exercises provide students the chance to develop their theoretical understanding and problem-solving skills. This ensures that students have understood the work and can apply it to real life situations. These are formatively assessed.
• Following a demonstration lecture, and a computer workshop in the Epiphany Term, undergraduates work on gaining information about a particular protein by researching structural data obtained by X-ray diffraction in the literature. This is followed by a project group discussion with undergraduates pooling results and then writing up their findings individually. The project is summatively assessed.

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